Some Symptoms Of Pyroluria Include But Are Not Limited To:
What Is Pyroluria?
Pyroluria is known by many different names including Pyrrole Disorder, Kryptopyrrole, Kryptopyrroluria,Pyrroluria, Pyrolle Disorder, Mauve Factor and Hemepyrrole.
Pyroluria is best described as the abnormal synthesis and metabolism of any heme producing molecule, including the oxygen carrying molecule hemoglobin. All cells in the body produce by-products (waste), and the by-product of heme metabolism is a metabolite called hydroxyhemopyrrolin-2-one (HPL), also known as Mauve Factor. The metabolite was originally thought to be a Kryptopyrrole, but further studies have proven that this is not the case.
Pyroluria sufferers produce excessive amounts of HPL, which renders the receptors on cells unable to utilize Zinc, Vitamin B6, Biotin . HPL also prevents the proper manufacture of Gamma Linolenic Acid (GLA), an important Omega 6 fat.
Supplementation with these nutrients is essential to reduce the detrimental effects of elevated HPL and to reduce the severity of the signs and symptoms associated with Pyroluria.
There is some evidence that suggests Pyroluria is genetically based, especially if a parent, grandparent, aunt, uncle, brother or sister has suffered from major Depression, Bi-Polar Disorder, Alcoholism, Schizophrenia or has suicided. What we have found through treating many sufferers of Pyroluria, is that certain lifestyle factors also contribute to or exacerbate Pyroluria, and it's associated signs and symptoms. Addressing inadequate digestion, leaky gut syndrome, dysbiosis, an improper diet and stress are essential in any treatment protocol in addressing Pyroluria.
Poor diet and digestive health can lead to an increase in HPL levels . This makes sense as insufficient nutritional intake from a poor diet and inadequate digestion, robs the body of essential nutrients causing deficiencies. This places greater stress on the body and further inflates HPL levels.
Leaky Gut Syndrome or intestinal permeability, is a condition whereby microscopic holes occur in the intestinal wall allowing undigested food, bacterial by-products, poisons and toxins to pass into the bloodstream. Leaky Gut Syndrome is commonly found in Pyroluria sufferers and further contributes to the elevation of HPL.
Studies have shown that zinc deficiency increases Leaky gut Syndrome in animal and humans.
It is a well known fact that stress damages the intestinal wall causing intestinal inflammation, which leads to an increase in Leaky Gut Syndrome.
Dysbiosis, frequently found in Pyroluria sufferers, is an overgrowth of detrimental organisms within the intestinal tract. Dysbiosis is linked to increased HPL levels as well as a cause of Leaky Gut Syndrome. Stress increases the adherence of bad bacteria to the intestinal wall within 30 minutes.
Pioneering Pyroluria researcher, Dr Carl Pfeiffer, stated on more that one occasion that stress is a major driver behind elevated HPL. Research confirms this and has shown that elevated stress levels can indeed increases the production of HPL. A non published US navy study conducted in 1992, found a very rapid increase in HPL levels in male volunteers who were subjected to the stress of a brief cold-water immersion.
Alcohol, smoking, drugs and heavy metal exposure also increase HPL levels. This is why sufferers of Pyroluria tend to get a worsening of their symptoms 24 to 48 hours after a big night out drinking or after recreational drug use.
Most Common Signs and Symptoms
1. Being anxious, shy, or fearful or experiencing inner tension since childhood, but hiding these feelings from others 2. Having bouts of depression or nervous exhaustion 3. Poor dream recall, stressful or bizarre dreams, or nightmares (low vitamin B6) 4. Excessive reactions to tranquilizers, barbiturates, alcohol, or other drugs, in which a little produces a powerful response (low vitamin B6) 5. Preferring not to eat breakfast, experiencing light nausea in the morning, or being prone to motion sickness (low vitamin B6) 6. White spots or flecks on the fingernails or opaquely white or paper-thin nails (low zinc) 7. Liquid zinc sulfate having a mild taste or tasting like water (low zinc) 8. Poor appetite or having a poor sense of smell or taste (low zinc) 9. Joints popping, cracking, or aching; pain or discomfort between the shoulder blades; or cartilage problems (low zinc) 10. Pale or fair skin or being the palest in the family, or sunburning easily, now or when younger 11. Disliking protein or having ever been a vegetarian or vegan 12. Being sensitive to bright sunlight or noise 13. Upper abdominal pain on your left side under the ribs or, as a child, having a stitch in your side as you ran 14. Frequent fatigue
15. Being prone to iron anemia or low ferritin levels 16. Tending to have cold hands or feet 17. Having frequent colds or infections, or unexplained chills or fever 18. Reaching puberty later than normal or having irregular menstruation or PMS 19. Having allergies, adrenal issues, or problems with sugar metabolism 20. Having gluten sensitivity 21. Neurotransmitter imbalances, especially low serotonin 22. For women, belonging to an all-girl family or having look-alike sisters 23. For men, having a mother from an all-girl family or a mother with look-alike sisters, or all the females in the mother’s family bearing a strong resemblance to each other 24. Avoiding stress because it upsets your emotional balance 25. Tending to become dependent on one person whom you build your life around 26. Preferring the company of one or two close friends rather than a gathering of friends; becoming more of a loner as you age 27. Feeling uncomfortable with strangers 28. Being bothered by being seated in the middle of the room in a restaurant 29. Being easily upset by criticism
Less Common Signs And Symptoms
30. Stretch marks or poor wound healing (low zinc) 31. Crowded upper front teeth, many cavities, or inflamed gums or wearing braces (low zinc) 32. Bad breath and body odor (or a sweet, fruity odor), especially when ill or stressed (low zinc) 33. Being prone to acne, eczema, herpes, or psoriasis 34. Reduced amount of hair on your head, eyebrows, or eyelashes, or prematurely gray hair 35. Difficultly recalling past events and people in your life 36. Focusing internally, on yourself, rather than on the external world 37. Tending to have morning constipation 38. Tingling sensations or muscle spasms in your legs or arms 39. Feeling stressed by changes in your routine, such as traveling or being in new situations 40. Your face looking swollen when you’re under a lot of stress 41. Cluster headaches or blinding headaches 42. One or more of the following: a psychiatric disorder, schizophrenia, high or low histamine, alcoholism, learning and behavioral disorders, autism, or Down syndrome.
If you check off 15 or more items, especially the more common ones, it’s highly probable that you have pyroluria and will benefit from taking zinc and vitamin B6 supplements. I encourage you to be tested (keep in mind that your pyroluria urine test may come back with a false negative), but if this isn’t possible, or even if you don’t have pyroluria, supplementing with zinc and vitamin B6 may be worthwhile if you have a large number of these symptoms.